식품의 기준 및 규격 · 제8편 일반시험법분석조건 18.2.2.2

수산물 중 동물용의약품 동시 다성분 시험법

식품의약품안전처 고시 제2026-55호 「식품의 기준 및 규격」 제8. 일반시험법

이 페이지는 고시 원문의 크로마토그래프 분석조건만 뽑아 정리한 것입니다. 시험 전체 절차(검체 조제, 시스템적합성 기준, 계산식 등)는 담고 있지 않으니, 실제 시험 수행과 판정은 반드시 고시 원문을 확인하십시오.

분석조건

분석조건

LC기울기 용리8.2.2.2FD-수산물-중-동물용의약품-동시-다성분-시험법-x1

원문 표제 단서: 액체크로마토그래프

칼럼
C18 · USP L1

C18계 컬럼

안지름 2.1 mm · 길이 15 cm · 입자경 3.5 μm

칼럼온도
40℃
이동상
  • 0.1%(v/v) 포름산(formic acid) 함유한 수용액
  • 2 mM 포름산암모늄(ammonium acetate) 및 0.1% 포름산(formic acid) 함유한 아세토니트릴
유량
0.3 mL/분
주입량
5 μL
기타표
구분,정량한계계열,동물용의약품,넙치,장어,새우린코사마이드계,린코마이신,0.001,0.001,-클린다마이신,0.005,0.005,-마크로라이드계,스피라마이신,-,-,-에리스로마이신,0.001,0.001,-올레안도마이신,0.01,0.01,0.01조사마이신,0.001,0.001,0.001틸미코신,0.01,0.01,0.01키타사마이신,-,-,-벤조이미다졸계,메벤다졸,0.01,0.01,0.01메벤다졸 아민,0.01,0.01,0.015-하이드록시 메벤다졸,0.01,0.01,0.01티아벤다졸,0.01,0.01,0.015-하이드록시 티아벤다졸,0.01,0.01,0.01설파계,설파구아니딘,0.005,0.005,0.005설파독신,0.001,0.001,0.001설파디메톡신,0.001,0.001,0.001설파디아진,0.001,0.001,0.001설파메라진,0.001,0.001,0.001설파메타진,0.001,0.001,0.001설파메톡사졸,0.001,0.001,0.001설파메톡시피리다진,0.001,0.001,0.001설파모노메톡신,0.001,0.001,0.001설파퀴녹살린,0.001,0.001,0.001설파클로르피리다진,0.001,0.001,0.001설파클로르피라진,0.001,0.001,0.001설파티아졸,0.001,0.001,0.001설파페나졸,0.001,0.001,0.001설피속사졸,0.001,0.001,0.001세팔로스포린계,세파드록실,0.001,0.001,-세팔렉신,0.005,0.005,0.005세프티오퍼,-,-,-데스후로일세프티오퍼,-,-,-퀴놀론계,날리딕스산,0.0001,0.0001,0.0001노르플록사신,0.0007,0.0007,0.0007다노플록사신,0.01,0.01,0.01디플록사신,0.001,-,-마보플록사신,0.0001,0.0001,0.0001시프로플록사신,0.0001,0.0001,0.0001엔로플록사신,0.0001,0.0001,0.0001오플록사신,0.0002,0.0002,0.0002옥소린산,0.0001,-,0.0001페플록사신,0.0007,0.0007,0.0007플루메퀸,-,-,-테트라싸이클린계,독시싸이클린,0.005,0.005,0.005옥시테트라싸이클린,0.001,0.001,0.001클로르테트라싸이클린,0.001,0.001,0.001테트라싸이클린,0.001,-,0.001미노싸이클린,0.01,-,0.01페니실린계,벤질페니실린,0.01,0.01,0.01아목시실린,0.005,-,-암피실린,0.005,0.005,0.005클록사실린,0.01,0.01,0.01페니콜계,플로르페니콜,-,-,-플로르페니콜 아민,-,-,-티암페니콜,-,-,-클로람페니콜,-,-,-기타,데하이드로콜산,0.005,0.005,0.005디아베리딘,0.01,0.01,0.01비치오놀,-,-,-에토파베이트,0.01,0.01,0.01m-페네티딘,0.01,0.01,0.01오르메토프림,-,-,-트리메토프림,0.001,0.001,0.001트리클로르폰,0.001,0.001,-티아물린,0.001,0.001,-페노뷰카브,0.001,0.001,0.001푸마길린,-,-,-프라지콴텔,0.001,0.001,0.001
질량분석(MS) 조건 보기 (5항목)
이온화 방법
가) 이온화 방법: ESI(Positive ion mode, Negative ion mode)
Capillary temperature
나) Capillary temperature: 500℃
Capillary voltage
다) Capillary voltage: 3.8 kV(Positive), 2.6 kV(Negative)
Collision gas
라) Collision gas: 아르곤(Ar) 또는 이와 동등한 것
전이표
연번분석성분 (Compound)머무름 시간 (분)이온화(Ionization mode)분자량 (MW)관측질량 (Exact mass)선구이온 (Precusor ion, m/z)생성이온 (Product ion, m/z)충돌에너지 (Collision energy, eV)
1날리딕스산 (Nalidixic acid)6.77Positive232.2232.08233104 187 2151)36 25 12
2노르플록사신 (Norfloxacin)3.27Positive319.3319.13320233 2761) 30220 15 20
3다노플록사신 (Danofloxacin)3.56Positive357.4357.14358231 3141) 34030 15 20
4데하이드로콜산 (Dehydrocholic acid)7.41Negative402.5401.104012151) 249 33130 32 23
5독시싸이클린 (Doxycycline)5.01Positive444.4444.15445267 321 4281)34 29 16
6디아베리딘 (Diaveridine)2.83Positive260.2260.1326181 1231) 24540 25 28
7디플록사신 (Difloxacin)4.21Positive399.4399.134002991) 356 38225 20 20
8린코마이신 (Lincomycin)2.76Positive406.5406.214071261) 172 35930 20 18
9마보플록사신 (Marbofloxacin)3.11Positive362.4362.13363721) 320 34520 15 20
10메벤다졸 (Mebendazole)6.46Positive295.2295.09296104 165 2641)30 40 20
10-1메벤다졸 아민 (Mebendazole amine)4.51Positive237.2237.092381051) 133 16025 30 25
10-25-하이드록시 메벤다졸 (5-hydroxy mebendazole)4.50Positive297.3297.1129879 160 2661)35 35 20
11미노싸이클린 (Minocycline)3.02Positive457.5457.18458283 3521) 44143 28 15
12벤질페니실린 (Benzylpenicillin, Penicillin G)6.58Positive334.4334.09335114 1601) 17630 15 15
13비치오놀 (Bithionol)10.4Negative356.0354.903551611) 163 19428 28 25
14설파구아니딘 (Sulfaguanidine)1.13Positive214.2214.0521560 92 1561)12 10 5
15설파독신 (Sulfadoxine)5.00Positive310.3310.0731192 108 1561)28 24 16
16설파디메톡신 (Sulfadimethoxine)5.96Positive310.3310.07311921) 108 15628 26 18
17설파디아진 (Sulfadiazine)2.63Positive250.2250.0525192 108 1561)26 22 14
18설파메라진 (Sulfamerazine)3.33Positive264.3264.0626592 108 1561)24 22 16
19설파메타진 (Sulfamethazine)3.87Positive278.3278.0827992 124 1861)28 22 16
20설파메톡사졸 (Sulfamethoxazole)5.02Positive253.2253.0525492 108 1561)26 20 14
21설파메톡시피리다진 (Sulfamethoxypyridazine)3.97Positive280.3280.0628192 108 1561)30 25 14
22설파모노메톡신 (Sulfamonomethoxine)4.45Positive280.3280.0628192 108 1561)28 24 16
23설파퀴녹살린 (Sulfaquinoxaline)5.98Positive300.3300.0630192 108 1561)22 22 17
24설파클로르피라진 (Sulfachlorpyrazin, Sulfaclozine)4.66Positive284.7284.0128592 108 1561)26 24 14
25설파클로르피리다진 (Sulfachlorpyridazine)5.85Positive284.7284.0128592 108 1561)24 22 14
26설파티아졸 (Sulfathiazole)2.91Positive255.3255.01256921) 108 15624 22 15
27설파페나졸 (Sulfaphenazole)6.08Positive314.4314.0831592 1581) 16034 28 22
28설피속사졸 (Sulfisoxazole)5.33Positive267.3267.0626892 1131) 15631 16 14
29세파드록실 (Cefadroxil)1.60Positive363.4363.083641141) 20815 10
30세팔렉신 (Cefalexin)3.14Positive347.4347.09348106 1581) 17426 10 14
31세프티오퍼 (Ceftiofur)5.57Positive523.6523.0252495 125 2411)42 58 16
31-1데스후로일세프티오퍼 (Desfuroylceftiofur)4.55Positive429.5429.024301281) 259 36825 18 15
32스피라마이신 (Spiramycin)4.55Positive843.1842.51422101 142 1741)12 10 18
33시프로플록사신 (Ciprofloxacin)3.40Positive331.3331.13332204 231 2451)53 35 19
34아목시실린 (Amoxicillin)1.39Positive365.4365.10366113 133 3491)19 31 5
35암피실린 (Ampicillin)3.12Positive349.4349.1135079 1061) 11444 17 30
36에리스로마이신 (Erythomycin)6.16Positive733.9733.4673482 1581) 57635 25 18
37에토파베이트 (Ethopabate)5.84Positive237.2237.10238136 164 2061)25 20 10
37-1m-페네티딘 (m-phenetidine)3.04Positive137.1137.0813865 93 1101)20 25 10
38엔로플록사신 (Enrofloxacin)3.71Positive359.4359.16360189 2451) 28640 23 32
39오르메토프림 (Ormethoprim)3.48Positive274.3274.1427581 1231) 25943 25 27
40오플록사신 (Ofloxacin)3.29Positive361.4361.14362221 2611) 31835 28 15
41옥소린산 (Oxolinic acid)5.45Positive261.2261.06262129 1601) 17335 28 17
42옥시테트라싸이클린 (Oxytetracycline)3.41Positive460.4460.14461201 337 4261)18 40 28
43올레안도마이신 (Oleandomycin)5.83Positive687.9687.41688116 1581) 54440 25 15
44조사마이신 (Josamycin)7.59Positive828.0827.4682883 1091) 17440 45 34
45클로람페니콜 (Chloramphenicol)5.61Negative323.1322.013211521) 194 25718 12 10
46클로르테트라싸이클린 (Chlortetracycline)4.77Positive478.9478.1147998 1541) 44440 24 22
47클록사실린 (Cloxacillin)7.89Positive435.9435.06436159 178 3211)10 20 15
48클린다마이신 (Clindamycin)4.98Positive425.0424.174261261) 335 37725 18 15
49키타사마이신 (Kitasamycin)6.93Positive785.9701.4077283 1091) 17445 38 30
50테트라싸이클린 (Tetracycline)3.72Positive444.4444.154451541) 225 41024 50 16
51트리메토프림 (Trimethoprim)3.18Positive290.3290.13291123 2301) 26130 18 25
52트리클로르폰 (Trichlorfon)4.28Positive257.4255.9225979 1091) 22325 18 10
53티아물린 (Tiamulin)6.91Positive493.7493.3249473 1191) 19250 40 20
54티아벤다졸 (Thiabendazole)2.72Positive201.2201.0420292 131 1751)30 25 25
54-15-하이드록시 티아벤다졸 (5-hydroxy thiabendazole)1.91Positive217.2217.0321881 108 1471)35 30 25
55티암페니콜 (Thiamphenicol)3.70Positive356.2355.00354185 240 2901)20 16 12
56틸미코신 (Tilmicosin)5.39Positive869.1868.5687088 126 1741)60 55 45
57페노뷰카브 (Fenobucarb)8.63Positive207.2207.1320857 95 1521)15 15 5
58페플록사신 (Pefloxacin)3.34Positive333.3333.143342331) 290 31623 16 18
59푸마길린 (Fumagillin)9.27Positive458.5458.234591311) 177 23325 15 12
60프라지콴텔 (Praziquantel)8.12Positive312.4312.1831383 174 2031)22 28 14
61플로르페니콜 (Florfenicol)5.14Negative358.2357.00356118 1851) 33640 21 13
61-1플로르페니콜 아민 (Florfenicol amine)1.11Positive247.2247.0624891 130 2301)42 25 10
62플루메퀸 (Flumequine)7.03Positive261.2261.08262991) 126 20254 44 30

기울기 조건표

시간(분)A(%)B(%)
0.09010
1.09010
6.06040
10.0595
15.0595
15.19010
20.09010
이 조건으로 Core-Shell 전환 계산하기

이 조건의 칼럼 사양·유량이 크로마톡 계산기에 채워진 채로 열립니다.

고시 원문 보기 (축자)
가) 컬럼: C18계 컬럼(2.1 mm × 150 mm, 3.5 μm) 또는 이와 동등한 것
나) 이동상
(1) 이동상 A: 0.1%(v/v) 포름산(formic acid) 함유한 수용액
(2) 이동상 B: 2 mM 포름산암모늄(ammonium acetate) 및 0.1% 포름산(formic acid) 함유한 아세토니트릴
[표 1]
다) 이동상 유량: 0.3 mL/분
라) 컬럼 온도: 40℃
마) 주입량: 5 μL
2) 질량분석기 분석조건
가) 이온화 방법: ESI(Positive ion mode, Negative ion mode)
나) Capillary temperature: 500℃
다) Capillary voltage: 3.8 kV(Positive), 2.6 kV(Negative)
라) Collision gas: 아르곤(Ar) 또는 이와 동등한 것
마) 분석대상물질 조건
[표 2]
1) 정량이온
3) 검량선 작성
4) 정량한계
(단위: mg/kg)
※ 정성만 가능한 물질은 ‘-’로 표시
[표 3]

고시 원문의 표기·오탈자·조판 잔재를 고치지 않고 그대로 옮겼습니다.

상 분류 C18USP L1 상당

약전 일반명 '액체크로마토그래프용옥타데실실릴실리카겔'(USP 분류로는 L1 상당)에 해당. 약전은 브랜드를 지정하지 않으므로 각조가 기재한 물리 사양(치수·입자경 등)과 KP 통칙·일반시험법의 조정 허용범위 안에서 해당 상을 충족하는 C18을 선택할 수 있다 — 선택 기준은 시스템적합성(분리도·테일링·RSD) 통과 용이성과 재현성이다.

같은 고정상을 쓰는 다른 품목

한 컬럼으로 몇 개 시험을 함께 받을 수 있는지 볼 때 씁니다.

공전이 개정되면

고시가 개정되면 이 페이지의 분석조건도 함께 갱신됩니다. 어떤 항목이 어떻게 바뀌었는지는 크로마톡 규제·약전 브리핑에 정리해 올립니다.

최신 규제·공전 개정 브리핑 보기 →

출처: 식품의약품안전처 고시 제2026-55호 「식품의 기준 및 규격」 제8. 일반시험법. 국내 고시는 저작권법 제7조에 따른 비보호 저작물이며, 이 페이지는 원문의 분석조건을 기계적으로 정리하고 원문을 축자 병기한 것입니다. 원문의 오탈자·조판 잔재는 고치지 않고 보존했습니다.

식품공전 분석조건 전체 목록으로

서버 연결 확인 중...