Biozen™ Portfolio • Aggregate Analysis (SEC) • Fragment/Sub-Unit Analysis (SEC & RP) • Native MS/Intact Mass (SEC & IEX & RP) • Oligonucleotide Characterization (RP) • Charge Variant Analysis (IEX) • Peptide Quantitation (RP) • Peptide Mapping (RP) • Average Drug Antibody Ratio (SEC & RP) • Glycan Mapping (HILIC) * Patented Titanium (BioTi™) infused biocompatible hardware * Resolution of monomer and aggregate species for AAV’s through 700Å pore size * Resolution driven by an optimized pore size and inert particle chemistry * Method robustness for a variety of AAV serotypes * Highly reproducible for consistency in identification Questions?