Phenomenex Product Solutions for Characterization of Biomolecules * Overview • Complexity & Structure of Biomolecules • Biozen Product Portfolio for characterization of biomolecules • Fragment & aggregate analysis – Biozen dSEC-2 & SEC-3 • AAV Characterization – Biozen dSEC-7 • Intact Mass, ADCs and Middle down analysis – Biozen Widepore C4 & C8 • Peptide Mapping and sequence variant analysis - Biozen Peptide XB-C18, PS C18 and Polar C18 • Glycan mapping - Biozen Glycan & Biozen Glycan Cleanup • Charge variant analysis - Biozen WCX • DAR Distribution – Biozen Native RP-1 & 5 • Omics applications - Biozen Nano LC columns • Affinity Binding & Immunocapture - Biozen Magnetic Beads • Oligonucleotide Workflows – Biozen Oligo and Clarity * Complexity & Structure of Biomolecules • mAbs/ADCs/Biosimilars • Critical Quality Attributes • AAVs • Oligonucleotides * Biozen Products Portfolio • Biozen™ Portfolio • Aggregate Analysis (SEC) • Fragment/Sub-Unit Analysis (SEC & RP) • Native MS/Intact Mass (SEC & IEX & RP) • Oligonucleotide Characterization (RP) • Charge Variant Analysis (IEX) • Peptide Quantitation (RP) • Peptide Mapping (RP) • Average Drug Antibody Ratio (SEC & RP) • DAR Distribution (Native RP) • Glycan Mapping (HILIC) • Affinity Binding (Immunocapture) • Biozen Size Exclusion Columns • Fragment & Aggregate Analysis • Biozen Widepore Reverse Phase Columns • Intact Mass & Sub-unit Analysis – Middle Down Platform Method • Biozen Narrowpore Reverse Phase Columns • Peptide Mapping & Sequence Variant Analysis • Biozen Glycan HILIC Column • Biozen N-Glycan Clean-up SPE Plates • Glycan Mapping – Separation of Neutral & Charged Glycans • Biozen WCX – Cation Exchange Column • Charge Variants Analysis – Salt Vs. pH Gradient • Biozen Native RP-1 & 5 • DAR Distribution – Native RP-MS • Biozen Nano Columns & Traps • Omics Applications • Biozen Paramagnetic Beads • Clarity BioSolutions & Biozen Oligo • Oligonucleotide Extraction From Biological Matrices – Clarity OTX • Purification of DMT-On Synthetic Oligonucleotides – Clarity QSP • BNA Gapmer Oligonucleotide Stainless Steel Vs. BioTi • BNA Oligonucleotide Standard * Questions?